College football · all-time series
Clemson vs. Louisville
Clemson
ACC
Louisville
ACC9–1
10 meetings
Series leaderClemson by 8
Series span2014–2025
Current streakClemson 1
Largest marginClemson by 61
Score archive
Recent meetings
2025Nov 15, 2025
Clemson20
Louisville19
L&N Federal Credit Union Stadium
2024Nov 2, 2024
Louisville33
Clemson21
Memorial Stadium (Clemson, SC)
2022Nov 12, 2022
Louisville16
Clemson31
Memorial Stadium (Clemson, SC)
2021Nov 6, 2021
Clemson30
Louisville24
L&N Federal Credit Union Stadium
2019Oct 19, 2019
Clemson45
Louisville10
L&N Federal Credit Union Stadium
2018Nov 3, 2018
Louisville16
Clemson77
Memorial Stadium (Clemson, SC)
2017Sep 17, 2017
Clemson47
Louisville21
L&N Federal Credit Union Stadium
2016Oct 2, 2016
Louisville36
Clemson42
Memorial Stadium (Clemson, SC)
2015Sep 17, 2015
Clemson20
Louisville17
L&N Federal Credit Union Stadium
2014Oct 11, 2014
Louisville17
Clemson23
Memorial Stadium (Clemson, SC)